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pentobarbital decreases levels of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. CYP3A4 inducers increase charge of toremifene metabolism, reducing the continual-point out concentration in serum.pentobarbital will minimize the level or result of ondansetron by impacting hepatic/intestinal enzyme CYP3A4 metab